Bupropion — what it treats, what it costs

What it should cost to fill

Strength	Cash price	With a discount card
150 mg SR (twice daily)	$13 – $80	$7 – $26
150 mg XL (once daily)	$15 – $90	$8 – $30
300 mg XL (once daily)	$18 – $100	$10 – $34

Typical retail ranges, not quotes. What you are charged depends on the pharmacy and on how the claim is processed — which is exactly why it is worth asking.

Where the money goes

SR and XL are different formulations at different prices and are not interchangeable dose-for-dose.

What else there is

Not recommendations. The tradeoff matters more than the name, and it is the part a prescriber will want to talk about.

SSRIs such as sertralineDifferent class

Different side-effect profile. Bupropion is often chosen specifically to avoid sexual side effects or weight gain, so the choice may be deliberate.

Worth asking

Am I on SR or XL, and does it matter for me?

Before you change anything.